ダイネインの方向性は,その茎の角度と長さによって制御されます
Sinan Can1, Samuel Lacey2, Mert Gur3
1Physics Department, University of California at Berkeley, Berkeley, CA, USA.
Nature
|February 8, 2019
まとめ
研究者達は 運動タンパク質のダイネインを 微小管のプラス端に移動させるように設計しました ダイネインの茎を修正する
科学分野:
- 分子生物学
- 細胞生物学
- バイオ物理学
背景:
- 細胞内輸送と細胞分裂に不可欠である.
- ほとんどのキネシンとミオシンモーターは,いくつかの例外を除いて,フィラメントの片側に移動します.
- 研究されたすべてのダイネインモーターは,マイクロチューブルのマイナス端に向かってのみ移動する.
研究 の 目的:
- ダイネインの運動方向性のメカニズムを調査する
- サッカロミセア・ダイネイン・モーターを設計し プラス・エンド・ダイレクト・モチリティを 実現する
- 微小管の動きに影響する
主な方法:
- クリオ電子顕微鏡
- 分子ダイナミクスシミュレーション
- 単一分子測定法
- サッカロミセス・セレヴィセア・ダイネインの工学
主要な成果:
- コイルされたコイル茎の延長または短縮は,マイクロチューブルの周りのダイネインの螺旋方向性を制御します.
- 茎の長さと角度を修正することで ダイネインの運動性がプラスに逆転しました
- 変化した茎の幾何学は,微小管に対するダイネインリンクの振動方向を変更する.
結論:
- ダイネイン茎の構造がマイナスエンドの方向性を決定する.
- 保存された茎構造は,すべての既知のダイネインがマイクロチューブルマイナス端に向かって移動する理由を説明します.
- ストークの改良は タンパク質の運動力学と進化の洞察を 提供します
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