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Updated: Dec 9, 2025

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デンドリット細胞におけるmRNA m6Aメチル化とYTHDF1によって制御される抗腫瘍免疫

Dali Han1,2,3, Jun Liu4,5,6, Chuanyuan Chen7,8,9

  • 1Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China. handl@big.ac.cn.

Nature
|February 8, 2019
PubMed
まとめ

メッセンジャーRNA (mRNA) N6-メチアデノシン (m6A) メチレーションは,YTHDF1によって調節され,耐久的な抗腫瘍免疫を制御する. YTHDF1欠乏症はCD8+ T細胞の反応を高め,免疫療法の有効性を高める.

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