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Updated: Jan 29, 2026

Induction and Validation of Cellular Senescence in Primary Human Cells
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L1は老化細胞のIFNを駆動し,年齢に関連する炎症を促進する

Marco De Cecco1, Takahiro Ito1, Anna P Petrashen1

  • 1Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA.

Nature
|February 8, 2019
PubMed
まとめ

細胞老化はLINE-1レトロトランポゾンを再活性化し,炎症と老化を誘発するインターフェロン反応を引き起こします. LINE- 1逆転写酵素を阻害すると,この炎症が軽減され,老化に関連した疾患の治療目標を示唆する.

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