マクロモレキュルの経口投与のための摂取可能な自己指向システム
Alex Abramson1, Ester Caffarel-Salvador1,2, Minsoo Khang1
1Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Science (New York, N.Y.)
|February 9, 2019
まとめ
新しい自己指向型ミリメートルスケールアプリケータ (SOMA) は,胃粘膜に薬が詰まったミリポストを展開することで,バイオマクロモリケールの経口投与を可能にします. このシステムは,注射に匹敵する全身の薬物吸収を達成し,胃腸の分解の制限を克服します.
科学分野:
- バイオマテリアル科学
- 胃腸内科
- 薬物投与システム
背景:
- バイオマクロモリクルは治療的な可能性を持ちますが,口服での投与では,迅速な分解と消化器の吸収が悪いため,課題に直面しています.
- 親腸投与はしばしば必要であり,患者の従順性と便利性を制限する.
研究 の 目的:
- 胃腸の障壁を克服できる 革新的な経口生物学的投与システムを開発する
- 薬剤の投与に適した組織結合を保証する自己指向の適用器を作り出す.
主な方法:
- カメの動きからインスピレーションを得た,摂取可能な自己指向型ミリメートルスケールアプリケータ (SOMA) の開発.
- 粘膜部署のための活性薬剤を含むミリポストの製造.
- 安全性と有効性を評価するためにネズミと豚の体内試験.
主要な成果:
- SOMAは自律的に指向し,穴を開けずに胃腸組織と接触します.
- 薬剤の有効成分を運ぶ ミリポストの導入に成功しました
- 動物のモデルでは,皮下投与と比較できる全身性プラズマインスリン濃度を達成した.
結論:
- SOMAシステムは バイオマクロモリケルの経口投与における 重要な進歩を表しています
- この技術は胃腸内での薬の浸透と局所化を強化します.
- SOMAは生物学的薬剤投与のための親腸経路の有望な代替手段を提供します.
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