コリンアセチルトランスフェラーゼを発現するT細胞は,慢性ウイルス感染を制御するために必要である
Maureen A Cox1, Gordon S Duncan1, Gloria H Y Lin1
1The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.
まとめ
コリンアセチルトランスフェラーゼ (ChAT) によって調節されるT細胞由来アセチルコレンの生成は,抗ウイルス免疫に不可欠です. T細胞におけるChATの障害は,免疫細胞の移動と感染中のウイルス制御を危うくする.
科学分野:
- 免疫学
- 神経科学
- ウイルス学
背景:
- アセチルコリン (ACh) は神経伝達物質として知られています.
- 免疫におけるT細胞由来ACHの役割が明らかになっています
- ウイルス感染症におけるリンパ球由来ACHの機能は不明である.
研究 の 目的:
- ウイルス感染症におけるT細胞由来アセチルコリン (ACh) の役割を調査する.
- ウイルス感染時に T 細胞で ACh 生成のメカニズムを解明する.
主な方法:
- マウスにおけるリンパ球性髄膜炎ウイルス (LCMV) 感染症の研究.
- CD4+およびCD8+T細胞におけるコルインアセチルトランスフェラーゼ (ChAT) の誘導を分析した.
- T細胞特有のChat削除モデルを使用した.
- T細胞の移動,血管拡張,ウイルス制御を評価した.
主要な成果:
- コリンアセチルトランスフェラーゼ (ChAT) は,LCMV感染中にT細胞で有意に誘導され,IL-21に依存した.
- 感染した組織への血管拡張と抗ウイルスT細胞移動を阻害するChatのT細胞特異的消去
- T細胞におけるChATの喪失は,慢性的なLCMV感染の制御を損なう結果となった.
結論:
- ウイルスの感染中に T 細胞における ChAT の重要な役割が示された.
- 抗ウイルスT細胞の移動と免疫をサポートする,T細胞由来ACHを含む新しい経路が特定されました.
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