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Chromosome Replication02:31

Chromosome Replication

10.6K
Before a cell can divide, it must accurately replicate all of its chromosomes, including the DNA and its associated histone and non-histone proteins.  This process begins at numerous origins of replication during the S phase of the cell cycle in each of a cell’s chromosomes simultaneously. Certain nucleotides can act as origins of replication, but these sequences are not well defined - especially in complex, multi-cellular, eukaryotic species. The length of DNA that spans an origin...
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Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

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While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
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DNA Replication02:40

DNA Replication

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DNA replication involves the separation of the two strands of the double helix, with each strand serving as a template from which the new complementary strand is copied.  After replication, each double-stranded DNA includes one parental or “old” strand and one “new” strand. This is known as semiconservative replication. The resulting DNA molecules have the same sequence and are divided equally into the two daughter cells.
Replication in Prokaryotes
DNA replication...
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Replication in Prokaryotes02:35

Replication in Prokaryotes

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Overview
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Replication in Eukaryotes02:31

Replication in Eukaryotes

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関連する実験動画

Updated: Jan 29, 2026

Genome-wide Determination of Mammalian Replication Timing by DNA Content Measurement
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複製 の タイミング は 3 次元 の ゲノム 組織 と 絡み合っ て いる

Jian Ma1, Zhijun Duan2

  • 1Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA.

Cell
|February 9, 2019
PubMed
まとめ

研究者はDNA複製のタイミングとゲノム組織を制御する早期の複製制御要素 (ERCE) を発見した. これらのシス作用の要素は,高次元のゲノム構造と機能に関する新しい洞察を提供します.

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G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome
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関連する実験動画

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08:06

Genome-wide Determination of Mammalian Replication Timing by DNA Content Measurement

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科学分野:

  • ゲノミクス
  • 分子生物学
  • エピジェネティクス

背景:

  • 空間的なゲノム組織は,DNA複製を含む様々なゲノムプロセスに影響を与えます.
  • 複製のタイミングを制御する規制要素を理解することは,ゲノム機能を理解するために極めて重要です.

研究 の 目的:

  • 空間的なゲノム組織とDNA複製のタイミングの関係を調査する.
  • 複製のタイミングとゲノムアーキテクチャを調節する新しいシス作用要素を特定する.

主な方法:

  • 空間的なゲノム組織データの分析
  • DNA複製のタイミングパターンの解剖
  • 新しい規制要素の特定と特徴付け

主要な成果:

  • 早期複製制御要素 (ERCE) の発見
  • ERCEは複製のタイミングを調整することが判明しました.
  • ERCEは転写と3次元ゲノム組織の複数の層に影響を与えます.

結論:

  • 早期複製制御要素 (ERCE) は,シス作用の規制要素の新しいクラスを表します.
  • これらの発見は,高次元のゲノム構造と機能の制御を理解する上で重要な意味を持つ.
  • この研究は,ゲノム調節に関するさらなる研究のための基盤を提供します.