小分子アゴニスト エジプティニューロペプチドY受容体 蚊の噛み
Laura B Duvall1, Lavoisier Ramos-Espiritu2, Kyrollos E Barsoum1
1Laboratory of Neurogenetics and Behavior, The Rockefeller University, New York, NY 10065, USA.
Cell
|February 9, 2019
まとめ
研究者らは,ニューロペプチドY型受容体7 (NPYLR7) を標的とする薬を用いて,蚊の人間への引き寄せを抑制する新しい方法を発見しました. この発見は蚊が媒介する病気を 制御する新しい戦略を示しています
科学分野:
- 神経科学
- 昆虫学
- 薬理学について
背景:
- 雌のエデス・エジプティ蚊は 卵の発達に不可欠な 血液栄養のために人間に強い魅力を表します
- この宿主探しの行動は 血液を食べた後に 一時的に抑制されます
研究 の 目的:
- ニューロペプチドY (NPY) に関するシグナル伝達が,エイデス・エジプティの宿主探求の長期的行動抑制における役割を調査する.
- 特定の受容体を特定し,病気の制御のために蚊の行動を調節できる小分子アゴニストを開発する.
主な方法:
- 主な標的としてNPY型受容体7 (NPYLR7) を識別するために49の予測されたAedes aegyptiペプチド受容体をスクリーニングした.
- 選択的NPYLR7アゴニストを見つけるために265,211の化合物をスクリーニングした.
- CRISPR-Cas9遺伝子編集を使用して,NPYLR7のヌル変異体を機能分析のために作成しました.
主要な成果:
- NPYLR7が蚊の宿主探し行動を 制御する薬の唯一の標的と特定されました
- 人への蚊の引き寄せを効果的に抑制する6つの非常に選択的なNPYLR7アゴニストを分離した.
- NPYLR7のヌル変異体は 行動抑制に障害があり 開発された薬剤に耐性があることが示されました
結論:
- ニューロペプチドYに関連するシグナル伝達,特にNPYLR7は,血液の食事後の蚊の引き寄せを抑制する上で重要な役割を果たします.
- 開発された選択的NPYLR7アゴニストは,蚊の行動を制御し,感染症の伝播を減らすための有望な新しいアプローチを提供します.
- この研究は,蚊の神経生物学を標的として 効果的なベクトル制御戦略の可能性を強調しています.
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