循環器疾患における循環器調節細胞死
Inna Rabinovich-Nikitin1, Brooke Lieberman1, Tami A Martino2
1The Institute of Cardiovascular Sciences, St Boniface Hospital Albrechtsen Research Centre, Department of Physiology and Pathophysiology, Rady College of Medicine, Max Rady Faculty of Health Sciences, University of Manitoba, Canada (I.R.-N., B.L., L.A.K.).
Circulation
|February 12, 2019
まとめ
日常リズムが心血管の健康と病気に影響し,毎日の心拍数と血圧に影響します. これらの生物学的リズムを理解することは 心臓治療の最適化と 患者の成果の改善の鍵です
科学分野:
- 心血管生物学
- クロノバイオロジー
- 細胞生理学
背景:
- 日常時計は,心臓血管機能における日々の生物学的リズムを調節し,心拍数と血圧に影響します.
- これらのリズムは 心血管の健康と 心血管疾患の進行の両方に 極めて重要です
研究 の 目的:
- サーカディアンリズムと 心血管疾患の病原性の関係を調べる
- 細胞の運命を左右する 細胞のプロセスとのつながりを強調する
主な方法:
- 昼間の時計と心血管リズムに関するヒトと動物の研究のレビュー
- 心筋梗塞,不血症再注射損傷,心不全における昼夜リズムの役割の分析.
- 細胞死経路 (アポトーシス,ネクロシス,オートファギー) のサーカディアン調節に関する調査
主要な成果:
- 24時間間の循環リズムが心臓血管のパラメータに大きな影響を与えます.
- 心臓治療のタイミングは,心血管の結果に影響を及ぼします.
- 心臓の耐性や傷害に対する感受性は,1日の時間によって異なります.
結論:
- 細胞の運命を制御する ホメオスタティックなプロセスと複雑に結びついています
- これらの細胞メカニズムの理解は 心血管疾患の最適治療戦略の開発に不可欠です
- サーカディアン経路をターゲットにすることで 心血管疾患の新たな治療方法が提供されるかもしれません
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