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Updated: Jan 29, 2026

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries
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Published on: August 12, 2019

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フォトレドックス触媒によるDNAエンコードライブラリ合成における露天アルキル化反応

James P Phelan1, Simon B Lang1, Jaehoon Sim1

  • 1Roy and Diana Vagelos Laboratories, Department of Chemistry , University of Pennsylvania , 231 South 34th Street , Philadelphia , Pennsylvania 19104-6323 , United States.

Journal of the American Chemical Society
|February 13, 2019
PubMed
まとめ

DNAでコードされたライブラリ (DEL) は薬物発見に不可欠ですが,多様なC ((sp3) 炭素が欠けています. この研究では,高度な触媒技術を使用して,DELの化学的多様性およびC ((sp3) 含有量を高めるための新しい方法が紹介されています.

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