胸腔大動脈手術を受ける患者の性別による差異
Jennifer Chung1, Louis-Mathieu Stevens2, Maral Ouzounian1
1University of Toronto, Canada (J.C., M.O., M.D.P.).
Circulation
|February 14, 2019
まとめ
女性の場合は 胸前動脈外科手術の後 症状が悪化します 女性の性別は独立して高い死亡率と脳卒中率を予測し,性別のケア戦略に関するさらなる研究が必要である.
科学分野:
- 心血管外科
- 胸大動脈疾患
- 性 に 基づく 医学
背景:
- 胸前動脈疾患の手術結果は改善しました
- セックスがこれらの結果に与える影響は まだ十分に理解されていません
研究 の 目的:
- 低体温循環停止による胸前大動脈手術後の 性別による結果の違いを調査する.
主な方法:
- 2002年から2017年の間に胸大動脈手術を受けた1653人の患者の分析.
- 病院での死亡,脳卒中,複合性疾患のエンドポイントを含むアウトカムを性別で比較する.
- 多変数ロジスティック回帰は,独立した結果の予測要因を特定します.
主要な成果:
- 女性は高齢で 併発症が多かったが 大動脈の根の再建は少なかった
- 女性では死亡率 (11% 対 7. 4%) と脳卒中 (8. 8% 対 5. 5%) が高かった.
- 女性の性別は死亡率,脳卒中,複合疾患の独立予測因子でした.
結論:
- 女性の場合は 胸腔大動脈の手術で 低体温で循環が停止すると より悪い結果が出ます
- 性別に基づく結果の格差を減らすための介入を特定するにはさらなる研究が必要です.
関連する概念動画
Thoracic Aorta
1.7K
The thoracic section of the aorta begins at the T5 vertebra and extends to the T12 level at the diaphragm, initially progressing through the mediastinum to the left of the spinal column. Throughout its course in the thoracic segment, the thoracic aorta emits various offshoots known collectively as visceral and parietal branches. The branches that predominantly supply blood to visceral organs are termed visceral branches and include bronchial, pericardial, esophageal, and mediastinal arteries,...
1.7K
Sex-linked Disorders
108.6K
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
108.6K
The Thoracic Cage: Sternum
6.0K
The thoracic or rib cage forms the body's thorax (chest) portion. Its primary function in the body is to protect vital organs in the thoracic cavity, such as the heart and the lungs. It consists of 12 pairs of ribs with their costal cartilages and the sternum. The ribs are anchored posteriorly to the 12 thoracic vertebrae (T1-T12).
The sternum is the elongated bony structure on the anterior side of the thoracic cage. It consists of three parts: the manubrium, the body, and the xiphoid...
The sternum is the elongated bony structure on the anterior side of the thoracic cage. It consists of three parts: the manubrium, the body, and the xiphoid...
6.0K
The Thoracic Cage: Ribs
8.6K
Ribs are curved, flattened bones forming the thoracic cavity wall with the thoracic muscles. There are 12 pairs of thoracic ribs. The posterior ends of all the ribs articulate with the T1–T12 thoracic vertebrae. In contrast,the anterior ends of most ribs attach to the sternum via their costal cartilages.
Parts of a Typical Rib
A typical rib has a head, neck, and body. The posterior end of the rib is called the head, followed by a narrow neck. The head articulates primarily with the costal...
Parts of a Typical Rib
A typical rib has a head, neck, and body. The posterior end of the rib is called the head, followed by a narrow neck. The head articulates primarily with the costal...
8.6K
Electric Potential and Potential Difference
5.7K
Suppose a positive test charge moves away from a positive static charge, then the Coulomb force does positive work, and its electric potential energy decreases. The potential energy per unit charge is defined as the electric potential. The electric potential is independent of the test charge.
When a test charge moves from the initial to the final position, the electric potential difference between those positions is defined as the ratio of the change in the potential energy to the charge on the...
When a test charge moves from the initial to the final position, the electric potential difference between those positions is defined as the ratio of the change in the potential energy to the charge on the...
5.7K
Difference from Background: Limit of Detection
8.3K
The limit of detection (LOD) is the smallest amount of analyte that can be distinguished from the background noise. The LOD value corresponds to the concentration at which the analyte signal is three times larger than the standard deviation of the blank signal. Below this value, the analyte signal cannot be differentiated from the background noise. It is calculated by dividing the calibration slope by 3 times the standard deviation of the blank signals.
The LOD indicates the presence or absence...
The LOD indicates the presence or absence...
8.3K


