睡眠は血液形成を調節し,動脈硬化症から保護する

Cameron S McAlpine¹, Máté G Kiss^1,2,3, Sara Rattik¹

¹Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Nature

|February 15, 2019

まとめ

睡眠障害は免疫細胞の生産を変えて心血管疾患のリスクを高めますこの研究ではネズミの睡眠,血球形成,動脈硬化防止を結びつける神経免疫軸が明らかになりました

科学分野:

神経科学
免疫学
心血管科学

背景:

睡眠は健康に不可欠で睡眠障害は心臓血管疾患と関連しています
睡眠と心血管の健康を結びつける細胞と分子メカニズムは十分に理解されていません

研究の目的:

睡眠が血液形成 (血液細胞形成) を調節し,マウスモデルで動脈硬化症から保護する方法を調査する.
睡眠が心血管に与える保護効果に関係する神経免疫経路を特定するためです

主な方法:

睡眠の断片化はマウスで誘発された.
特定の免疫細胞 (Ly-6C高単細胞),動脈硬化病変の大きさ,および神経ペプチドヒポクレチンのレベルを測定した.
遺伝子改変とヒポクレチン補充は因果関係を調査するために使用されました.

主要な成果:

睡眠の断片化は,マウスのLy-6C高単細胞を増加させ,動脈硬化症を悪化させた.
睡眠を断片化したマウスでは,ヒポクレチン濃度の低下が観察されました.
血液形成細胞におけるヒポクレチンシグナル伝達またはCSF1レベルを調節することで,睡眠の断片化がモノサイトおよび動脈硬化に与える影響を改善した.

結論:

睡眠は血液形成を調節し,ヒポクレチンを含む神経免疫軸を通して動脈硬化から保護します.
この軸は脳 (ヒポクレチン) と免疫系 (単細胞生成) と心血管の健康を結びつけています

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