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Updated: Jan 29, 2026

Detection of Protein Ubiquitination
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Published on: August 19, 2009

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ドット1LによるH2Bユビキチン化とH3メチル化とのクロストークのメカニズム

Evan J Worden1, Niklas A Hoffmann1, Chad W Hicks1

  • 1Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Cell
|February 16, 2019
PubMed
まとめ

ヒストンH2Bユビキチン化 (H2B-Ub) は,ヒストンH3K79のDot1Lメチル化を刺激する. このクロストークはH4の尾を巻き込み,ヒストンH3の形状の変化を誘導し,K79が活性遺伝子転写へのアクセスを可能にします.

キーワード:
ドット1Lクロマチンクリオ・エムヒストンメチル化核細胞構造生物学ユビキチン

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