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Updated: Jan 29, 2026

Averaging of Viral Envelope Glycoprotein Spikes from Electron Cryotomography Reconstructions using Jsubtomo
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ヒトPグリコプロテインによる基板と阻害剤の差別に関する構造的洞察

Amer Alam1, Julia Kowal1, Eugenia Broude2

  • 1Institute of Molecular Biology and Biophysics, ETH Zürich, Otto-Stern-Weg 5, 8093 Zürich, Switzerland.

Science (New York, N.Y.)
|February 16, 2019
PubMed
まとめ

パクリタキセルに結合するABCB1 (P- glycoprotein) の冷凍- EM構造は,その薬物結合ポケットを明らかにする. この可塑性はATPを水解する核酸結合ドメインに影響し,薬物輸送と耐性に影響します.

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