セックス・ディモルフィック・コントロール・オブ・ペアレント・ビヘイヴーア・オブ・メディアル・アミグダラ

Patrick B Chen¹, Rongfeng K Hu¹, Ye Emily Wu¹

¹Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Cell

|February 19, 2019

まとめ

中枢桃体 (MeA) は性特異的な親と幼児の行動に重要な役割を果たします. GABAergicニューロンは男性と女性の行動を異なる方法で制御し重要な神経機構を明らかにします

科学分野:

神経科学
行動内分泌学
遺伝学

背景:

性別による社会的行動の違い特に親のケアや攻撃性は種によって顕著です
性別二形態の行動の神経的基礎を理解することは性別特有の神経機構の洞察に不可欠です
中枢桃体 (MeA) は社会的行動に関与しているが,性二形子型行動におけるその特定の役割は完全に解明されていない.

研究の目的:

親と幼児の行動を調節する中枢桃体 (MeA) の性二形態的役割を調査する.
子犬の行動における性差のニューラル回路と分子基盤を探求する

主な方法:

中枢桃体 (MeA) のGABAergicニューロンの光遺伝的操作を利用した.
分子差を特定するために単細胞トランスクリプトミア分析を用いた.
制御された環境で親と幼児の行動を観察し,定量化しました.

主要な成果:

MeAにおけるGABAergicニューロンの活性化は,メスマウスにおける親の行動を促進する.
オスマウスの場合,これらの同じニューロンの活性化は,活動レベルに基づいて親または乳幼児の行動を差異的に促進します.
単細胞トランスクリプトミックは,特にGABAergicニューロン集団のMeA内の分子性差異を明らかにしました.

結論:

中枢桃体 (MeA) は,性的に二形的な機能を持つ子犬向け行動のための重要な神経節です.
MeAのGABAergicニューロンは,男性と女性の親と幼児の行動の調節に異なった役割を果たします.
MeA GABAergicニューロン内の遺伝子発現における性差異は,観察された行動二型化に寄与し,分子,細胞,および回路レベルの違いを行動に結びつける.

キーワード:

GABAergicニューロン整形する幼児殺し医学的な桃体オプトジェネティクス育児の行動シーケンシング性二型化シングルセル社会的行動

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