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ヒポカンプス・アクンベンスの三部位神経モチーフは,空間の食欲記憶を導きます
Stéphanie Trouche1, Vadim Koren1, Natalie M Doig1
1Medical Research Council Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, OX1 3TH Oxford, UK.
Cell
|February 19, 2019
まとめ
背中のCA1ヒポカンプスは 核アキュンベンスと直接接続し 場所と報酬の記憶を 行動に誘導します この経路は 特定のニューロン相互作用を使って 食欲を刺激します
科学分野:
- 神経科学
- 行動神経科学
- システム神経科学
背景:
- 海馬のピラミッド細胞 (PYRs) は空間的な記憶表現を作成します.
- 空間記憶と行動を結びつける 神経回路は完全に理解されていません
研究 の 目的:
- ヒポキャンパスの空間記憶が 行動を誘導する 神経基板を特定する
- 記憶誘導行動における背面CA1 (dCA1) から核アキュンベンス (NAc) 経路の役割を調査する.
主な方法:
- ネズミのdCA1→NAc経路におけるニューロン集合のモニタリング
- 細胞型の選択的光遺伝的操作を用いる.
- パルバルブミンを発現する高速スパイク内ニューロンの役割を調査する.
主要な成果:
- NAcへの直接的なdCA1ヒポカムスの接続が確認された.
- dCA1 PYRsは,フィードフォワード阻害によってNAc中型の脊髄神経を駆動する.
- この経路は,空間的な食欲記憶とNAcの活動をサポートし,背中のサブキュラムとは独立しています.
結論:
- dCA1→NAc経路は,辺縁運動界面として機能する.
- この回路は空間的な表現を 食欲的な行動に変換します
- 記憶による行動の 鍵となるメカニズムが明らかになりました
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