女性 の 突然 の 心臓 発作 死
M Anette E Haukilahti1, Lauri Holmström1, Juha Vähätalo1
1From Research Unit of Internal Medicine (M.A.E.H., L.H., J.V., T.K., J.T., J.P., H.H., M.J.J.), Medical Research Center Oulu, University of Oulu and University Hospital of Oulu, Finland.
Circulation
|February 20, 2019
まとめ
女性の突然心臓死 (SCD) は,しばしば高齢で発生し,不血性原因があります. SCDの女性は正常なECGを持っているかもしれませんが,彼らは複雑なリスク要因を示す左心房高縮マーカーも多く示しています.
科学分野:
- 心臓病科
- 病理学について
- 医学 研究
背景:
- 心臓病管理の進歩にもかかわらず,突然の心臓死 (SCD) は依然として死亡の重要な原因です.
- SCDのリスクプロファイリングと予防戦略は,男性と比較して女性では定義されていない.
- 性別特有のメカニズムとSCDのリスクマーカーの理解は,結果を改善するために不可欠です.
研究 の 目的:
- SCDを患っている女性の大群の解剖結果と死因を調査する
- 女性と男性のSCDの特徴を比較する.
- 前回の心電図 (ECG) の結果と男女のSCDを分析し分類する.
主な方法:
- 北フィンランドにおける 1998年から2017年の臨床および解剖データの包括的な収集であるFingesture研究からのデータを使用した.
- SCDを経験した5869人の被験者のデータを分析し,1101人の被験者 (25.3%の女性) に焦点を当てた.
- 男性と女性のSCDコホート間の人口統計,解剖,およびECGデータを比較した.
主要な成果:
- 女性SCD被験者は男性 (63. 5歳) よりも年上でした.
- 発血性心疾患は両性において主要な死因であったが,非発血性疾患は女性においてより一般的であった (28. 3% vs 24. 3%).
- 女性は心臓筋線維症と正常なECGの割合が高かったが,左心室高縮のECGマーカーも高かった.
結論:
- 女性は高齢でSCDを発症し,非発血病の原因になる可能性が高くなります.
- 心筋線維症の罹患率は,特にSCDの女性では高くなっています.
- SCDの女性は正常なECGを示しますが,特定の過剰増殖と再偏振異常はより一般的で,異なるリスクプロファイルを示唆します.
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