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Updated: Jan 28, 2026

Mapping the Binding Site of an Aptamer on ATP Using MicroScale Thermophoresis
08:09

Mapping the Binding Site of an Aptamer on ATP Using MicroScale Thermophoresis

Published on: January 7, 2017

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ディチオホスファート群の組み込みによって達成された強化された分散と極化相互作用は,RNAアプタマー-トロンビン複合体の劇的な結合親和性を引き出します

Martin Egli, Terry P Lybrand

    Journal of the American Chemical Society
    |February 23, 2019
    PubMed
    まとめ

    RNA アプタマーのリン酸基をディチオリン酸基に置き換えると,タンパク質結合親和性が著しく増加する. トロンビンとVEGFを標的にするアプタマーで見られるこの改変は,ネイティブRNAよりも1000倍強い結合をもたらします.

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