哺乳類におけるゲノムインプリントと生理学的プロセス
Valter Tucci1, Anthony R Isles2, Gavin Kelsey3
1Department of Neuroscience and Brain Technologies - Istituto Italiano di Tecnologia, via Morego, 30, 16163, Genova, Italy.
Cell
|February 23, 2019
まとめ
ゲノムインプリントは哺乳類の表遺伝現象で 独特に親遺伝子を表現し 特徴や脳の機能に影響を与えます このレビューは,開発と疾患におけるインプリントされた遺伝子の重要なマイルストーンとメカニズムをカバーしています.
科学分野:
- 遺伝学
- エピジェネティクス
- 発達生物学
背景:
- 哺乳類は2組の染色体を持ち 両方の親から遺伝物質を受け継いでいます
- ゲノムインプリントは,哺乳類の生理学にとって重要な親特異性アレル表現を含む顕著な例外です.
- エピジェネティック研究によって特定されたインプリントされた遺伝子は,親の起源に基づいて遺伝子の発現を調節します.
研究 の 目的:
- ゲノムインプリントの分野における重要な進歩をレビューする.
- インプリントされた遺伝子が影響するメカニズムや生物学的システムについて議論する.
- 脳機能と関連疾患における ゲノムインプリントの役割を強調する
主な方法:
- ゲノムインプリント研究における重要なマイルストーンの文献レビュー.
- ゲノムインプリントの既定および新興メカニズムの分析
- 生理学的システムにおけるインプリントされた遺伝子の役割に関する現在の理解の合成.
主要な成果:
- ゲノムインプリントは,表型表現に影響を与える確立された表遺伝的メカニズムです.
- インプリントされた遺伝子は哺乳類の発達と生理学において重要な役割を果たします
- ゲノムインプリントが脳機能や神経疾患に 大きく影響していることを示しています
結論:
- ゲノムインプリントは 広範な生理学的意味を持つ 根本的な表遺伝的プロセスです
- プリントされた遺伝子のさらなる研究は 脳の発達と病気を理解するために不可欠です
- インプリントメカニズムの理解は,インプリントに関連する障害のための潜在的な治療目標を提供します.
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