まとめ
冠動脈バイパス手術中にプロプラノロール塩化水素の長期治療を継続することは安全です. このアプローチは,処置前に薬を止めるのに比べて,胸痛と心律不全を軽減しました.
科学分野:
- 心臓病学 心臓病学
- アネステシオロジー アネステシオロジー
- 薬理学 薬理学とは
背景:
- プロプラノロル塩化水素の長期療法は,心血管疾患において一般的です.
- 冠動脈バイパス手術の周りのこの治療法の最適な管理は,議論の余地があります.
研究 の 目的:
- 冠動脈バイパス手術を受ける患者に対するプロプラノロール塩化水素療法継続または中止の影響を将来的に調査する.
主な方法:
- 119人の患者を3つのグループに分け,プロプラノロールを継続,プロプラノロールを徐々に減量,プロプラノロールを投与しなかった.
- 評価されたアウトカムには,胸の痛みの症状,心室動脈不整合,外科手術中の缺血,低血圧,ブラジカルディア,および死亡率が含まれていました.
主要な成果:
- プロプラノロールを継続した (A群) 患者は,プロプラノロールを中止した (B群) 患者と比較して,アンギナや心室不律の増加が著しく減少した.
- 術内イシュケミアは,対照群 (51%) とグループB (70%) と比較して,A群 (26%) でより少なく見られた.
- 低血圧,ブラジカルディア,バイパスからの脱出,心臓刺激剤の必要性,または死亡率において,グループ間で有意な違いは観察されなかった.
結論:
- 冠動脈バイパス手術の時間まで,プロプラノロル塩化水素の長期治療をフル投与で継続することは安全で有益です.
- この戦略は,イシュケミアや不律症などの外科手術後の心臓イベントを緩和するように見えます.
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