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Updated: Jan 28, 2026

Quantifying Agonist Activity at G Protein-coupled Receptors
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バイアスアゴニストのIFNγ受容体複合体の構造

Juan L Mendoza1,2,3, Nichole K Escalante4,5, Kevin M Jude1,2

  • 1Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA.

Nature
|March 1, 2019
PubMed
まとめ

研究者は,IFNγ信号複合体を視覚化するために,インターフェロン-γ (IFNγ) 受容体の変種を設計した. これは免疫反応の欠陥のメカニズムを明らかにし,治療の可能性のバイアス信号を持つ部分的アゴニストを特定しました.

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