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Updated: Jan 28, 2026

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors
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Published on: February 28, 2021

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サイトシン塩基エディターは,マウス胚で実質的なオフターゲットの単核酸変異を生成する

Erwei Zuo1,2, Yidi Sun3, Wu Wei4,5,6

  • 1Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Science (New York, N.Y.)
|March 2, 2019
PubMed
まとめ

ゲノム編集は 遺伝子変異を修正できますが 標的外効果は 追跡するのが難しいのです 新しい方法であるGOTIでは,CRISPR-Cas9とアデニン塩基エディタは,サイトシン塩基エディタとは異なり,標的外変異が少ないことが示されています.

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