哺乳類の近赤外線画像は,注射可能な自己動力網膜ナノアンテナを通して
Yuqian Ma1, Jin Bao2, Yuanwei Zhang3
1Hefei National Laboratory for Physical Sciences at the Microscale, Neurodegenerative Disorder Research Center, CAS Key Laboratory of Brain Function and Disease, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230026, China.
Cell
|March 5, 2019
まとめ
科学者たちは注射可能なナノ粒子を開発し ネズミに近赤外線 (NIR) を 見せることができました これは哺乳類には見えない光スペクトルです この画期的な発見により 日光と並行視が可能になり バイオインテグレーテッドデバイスの 新たな可能性が生まれました
科学分野:
- 眼科について
- ナノテクノロジー
- 神経科学
背景:
- オプシン特性により,哺乳類は可視光 (700 nm以下) を見る事が限られている.
- 目に見えない近赤外線 (NIR) の検出は 重要な技術的,生物学的な課題です
- NIR検出の既存の方法は生物学的統合が欠如し,しばしば侵襲的です.
研究 の 目的:
- 哺乳類がNIR光を感知できるようにする方法を開発する.
- 副作用を最小限に抑える NIRビジョンの バイオ・インテグレッテッド・システムを作ります
- 視覚増強のためのアップコンバージョンナノ粒子の可能性を探求する.
主な方法:
- 眼内注射可能な光受容体結合アップコンバージョンナノ粒子 (pbUCNP) の開発
- 網膜の光受容体にpbUCNPを固定して NIR光トランスデューサとして作用します
- シングルフォトレセプター記録,電気レチノグラム,皮質記録,マウスの視覚行動テストを用いて
主要な成果:
- pbUCNPを注入したマウスは,NIR光を感知する能力を示した.
- 治療を受けたマウスは NIR光のパターンと 精巧な NIR形を区別することができました
- NIRビジョンは,周囲の昼光と互換性があり,ネイティブビジョンと並行して機能しました.
結論:
- 注射可能なpbUCNPは,哺乳類で機能的なNIR光画像の視覚を成功させました.
- この技術は視覚増強と バイオ・インテグレーテッド・ナノデバイスに 新しいアプローチを提供します
- この方法は自然な視覚的限界を克服する 安全で効果的な方法です
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