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関連する概念動画

What is Variation?01:14

What is Variation?

18.4K
Apart from the measures of central tendency, distribution, outliers, and the changing characteristics of data with time, an important characteristic of any data set is its variation or spread. In some data sets, the data values are concentrated closely near the mean; in others, the data values are more widely spread out from the mean.
The range, standard deviation, standard error, and variance are the different measures of variation.
Range: The range is the difference between its maximum and...
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Variation01:19

Variation

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An important characteristic of any set of data is the variation in the data. In some data sets, the data values are concentrated closely near the mean; in other data sets, the data values are more widely spread out from the mean. The most common measure of variation, or spread, is the standard deviation, which is the square root of variance.
When independent and dependent variables are plotted on a scatter plot, the slope of a line is a value that describes the rate of change between the two...
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Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

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Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
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Variation of Atmospheric Pressure01:18

Variation of Atmospheric Pressure

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Change in atmospheric pressure with height is particularly interesting. The decrease in atmospheric pressure with increasing altitude is due to the decreasing gravitational force per unit area as we move away from the surface of the earth.
Assuming the air temperature is constant at a given altitude and that the ideal gas law of thermodynamics describes the atmosphere to a good approximation, one can find the variation of atmospheric pressure with height.
Let p(y) be the atmospheric pressure at...
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Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

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Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
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Coefficient of Variation01:10

Coefficient of Variation

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The coefficient of variation measures the dispersion of the data points or distribution around the mean. Using the coefficient of variation, we can compare two data series with drastically different means or different units of measurement. The coefficient of variation for a sample and a population is expressed as a percentage of the ratio of standard deviation to the mean.
The coefficient of variation is a practical statistical tool in finance. It allows investors to assess the volatility or...
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関連する実験動画

Updated: Jan 28, 2026

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches
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Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches

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メガベース長ハイパーミューテーションは 17p11.2 のヒトの構造変化に伴います

Christine R Beck1, Claudia M B Carvalho1, Zeynep C Akdemir1

  • 1Department of Molecular and Human Genetics, BCM, Houston, TX 77030, USA.

Cell
|March 5, 2019
PubMed
まとめ

この研究では,マイクロホモロジー媒介によるブレイク誘発複製 (MMBIR) がヒトゲノムにおける構造変異 (SV) を引き起こすことが明らかになりました. MMBIRは再配置部位の近くで変異を起こし 遺伝子に影響を与えます

キーワード:
CNV についてDNA 修復複雑な再編成ゲノム表記ゲノムに関する疾患ロングリードシーケンシング段階的に

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Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response
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Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response

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Variations on Negative Stain Electron Microscopy Methods: Tools for Tackling Challenging Systems
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Variations on Negative Stain Electron Microscopy Methods: Tools for Tackling Challenging Systems

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関連する実験動画

Last Updated: Jan 28, 2026

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches
09:35

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches

Published on: April 20, 2021

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Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response
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Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response

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Variations on Negative Stain Electron Microscopy Methods: Tools for Tackling Challenging Systems
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Variations on Negative Stain Electron Microscopy Methods: Tools for Tackling Challenging Systems

Published on: February 6, 2018

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科学分野:

  • 遺伝学
  • ゲノミクス
  • 分子生物学

背景:

  • ヒトゲノムの構造変異 (SV) は,様々な変異過程から生じる.
  • ゲノム不安定性の解読には 新しい再編成の背後にあるメカニズムを理解することが重要です

研究 の 目的:

  • 染色体17p11.2の再編成の基礎となる分子機構を調査する.
  • 再発的および非再発的構造変異形成イベントの両方を分析する.

主な方法:

  • ロングとショートリーディングのシーケンシング技術を利用した.
  • de novo染色体 17p11.2 の再編成の結果を分析した.

主要な成果:

  • 単核酸変異 (SNV) のクラスター化率が増加し,非再発的な再編成に関連した.
  • indelとSNVの形成は,コピー数の増加と減少の両方で,ブレイクポイントの交差点から1Mbまで発生することを発見しました.
  • 単一鎖DNAの関与を示唆するC > G変換置換を好むことが判明した.
  • マイクロホモロジー媒介によるブレイク誘発複製 (MMBIR) メカニズムを裏付ける強力な証拠を提供した.
  • 主に遺伝子の内にあるSNVとインデルとして発現する,MMBIRからの局所的な超変異負荷を検出した.

結論:

  • マイクロホモロジー媒介によるブレイク誘発複製 (MMBIR) メカニズムは,構造変異の形成に大きく寄与する.
  • MMBIRは遺伝子内の局所的ハイパーミューテーション (SNVとインデル) によって特徴づけられる追加の変異負荷を課します.