妊娠間隔と,以前に死産をした女性の不良出産との関連:国際コホート研究
Annette K Regan1, Mika Gissler2, Maria C Magnus3
1School of Public Health, Curtin University, Perth, WA, Australia.
Lancet (London, England)
|March 5, 2019
まとめ
死産後12ヶ月以内に妊娠した女性は 妊娠不良のリスクは高まりません この発見は,死産後の将来の妊娠のためのカウンセリングを支持します.
科学分野:
- 産婦人科
- 生殖 健康
- 生後流行病学
背景:
- WHOのガイドラインでは,妊娠間隔 (IPI) を生産後少なくとも2年,流産/流産後6ヶ月とすることを推奨しています.
- 死産後のIPIについては,具体的な勧告はありません.
- この研究では,死産後のIPIと,その後の出産の結果との関連を調査した.
研究 の 目的:
- 死産後の最適な妊娠間隔を 決めるためだ
- 死産後の短い妊娠間隔に関連した有害な出産のリスクを評価する.
主な方法:
- フィンランド,ノルウェー,西オーストラリアの出生記録を用いた国際コホート研究 (1980年−2016年).
- 前回の死産 (妊娠22週以上) のシングルトン妊娠を含む.
- 調整された確率比とメタ解析を用いて,IPIとその後の死産,早産,および妊娠年齢に対する小児 (SGA) 出産との関連を分析した.
主要な成果:
- 死産後のIPIの平均値は9ヶ月で,女性の63%が12ヶ月以内に妊娠した.
- 24~59ヶ月のIPIと比較して,短いIPI (12ヶ月未満) は,その後の死産,早産,SGA出産の確率の増加と関連しませんでした.
- 前回の死産の妊娠期間に基づいて,関連性の違いは観察されなかった.
結論:
- 死産後12ヶ月以内に妊娠することは一般的であり,次の妊娠で有害な結果のリスクが高いとは関係ありません.
- 発見は死産後の妊娠を 計画している女性のカウンセリングに役立つ.
- この結果は,高収入の環境における妊娠間隔に関する将来の勧告を導くかもしれません.
さらに関連する動画
関連する概念動画
Birth Control Methods
6.7K
Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although...
6.7K
Genome-wide Association Studies-GWAS
15.6K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
15.6K
Prediction Intervals
3.4K
The interval estimate of any variable is known as the prediction interval. It helps decide if a point estimate is dependable.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.
3.4K
Internal Energy
36.7K
The total of all possible kinds of energy present in a substance is called the internal energy (U), sometimes symbolized as E. Suppose a system with initial internal energy, Uinitial, undergoes a change in energy (transfer of work or heat), and the final internal energy of the system is Ufinal. Change in internal energy equals the difference between Ufinal and Uinitial.
36.7K
Confidence Intervals
10.6K
An unbiased point estimate is often insufficient to predict a population estimate, such as population mean or population proportion. In this scenario, a confidence interval is used. A confidence interval is an estimate similar to a sample proportion. However, unlike the point estimate which is a single value, the confidence interval contains a range of values. These values have lower and upper limits, known as confidence limits, and can be designated as L1 and L2, respectively.
A...
A...
10.6K
Internal Receptors
74.6K
Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
74.6K


