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Updated: Jan 28, 2026

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19F NMRを用いた酵素特異性における核酸転移の役割の定義

Blaine J Dow1, Shuja S Malik1, Alexander C Drohat1

  • 1Department of Biochemistry and Molecular Biology , University of Maryland School of Medicine , Baltimore , Maryland 21201 , United States.

Journal of the American Chemical Society
|March 8, 2019
PubMed
まとめ

ティミンDNAグリコシラーゼ (TDG) は,G·Tミズペアからチミンを特異的に除去し,変異を防ぐ. この研究では,TDGはDNA修復に不可欠なニュクレオチドの反転を調節することにより,文脈特異性を達成することが明らかになりました.

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