関連する実験動画
Updated: Jan 28, 2026

09:50
Preparation and Reactivity of Gasless Nanostructured Energetic Materials
Published on: April 2, 2015
10.6K
活力 の 交換 と 低 代謝 状態 は 病気 の 耐性 を 促進 する
Kirthana Ganeshan1, Joni Nikkanen1, Kevin Man1
1Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
Cell
|March 12, 2019
まとめ
免疫反応は エネルギー交換を誘発し 低代謝と低体温を引き起こします この免疫誘発の低代謝は,疾患耐性を促進し,組織耐性メカニズムとして進化した可能性がある.
科学分野:
- 免疫学
- 代謝に関する研究
- 生態免疫学
背景:
- 病原体に対する宿主の防御は エネルギー的に高価です
- 免疫の代謝コストとそのトレードオフは十分に理解されていません.
- 生態免疫学では 免疫が他の維持機能と 交換される可能性を示唆しています
研究 の 目的:
- 免疫活性化に関連した エネルギー交換を調査する
- 免疫系が誘発する エネルギーコストの生理学的結果を 決定する.
- 病気の耐性におけるこれらのトレードオフのメカニズムと影響を調査する.
主な方法:
- 免疫の活性化と生理学的変化の監視
- トール・ライク受容体4 (TLR4) 経路解析によるリポポリサカリド (LPS) の血液形成感知
- メタボロミクスと全ゲノム発現プロファイリングにより,代謝プログラムが特定される.
主要な成果:
- 免疫の活性化により ホメオテルミーとのエネルギー交換が起こり 低代謝と低体温を引き起こします
- このトレードオフは病気の行動とは無関係ですが,トール型受容体4 (TLR4) のシグナリングが必要です.
- 異なった代謝プログラムは,低代謝状態への入り込みと回復を調節する.
結論:
- 免疫系が誘発する低代謝は,エネルギーを節約し,感染時に病気の耐性を促進する.
- 低代謝のような エネルギー保存状態は 組織耐性のメカニズムとして進化したのかもしれません
- 免疫,代謝,そして病気の生存との間の重要な関連が明らかになりました.
関連する概念動画
Energetics of Solution Formation
7.4K
The formation of a solution is an example of a spontaneous process, which is a process that occurs under specified conditions without energy from some external source.
When the strengths of the intermolecular forces of attraction between solute and solvent species in a solution are no different than those present in the separated components, the solution is formed with no accompanying energy change. Formation of the solution requires the solute–solute and solvent–solvent...
When the strengths of the intermolecular forces of attraction between solute and solvent species in a solution are no different than those present in the separated components, the solution is formed with no accompanying energy change. Formation of the solution requires the solute–solute and solvent–solvent...
7.4K
The Eukaryotic Promoter Region
18.7K
The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences. The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
18.7K
The Eukaryotic Promoter Region
3.9K
3.9K
Anaphase Promoting Complex
3.4K
The stepwise destruction of specific proteins is necessary for the progression and completion of the cell cycle. Such proteins are ubiquitinated by ubiquitin ligases and then subsequently destroyed by the proteasome. The SCF (Skp1/Cullin/F-box) and the anaphase-promoting complex (APC) are two important ubiquitin ligases involved in cell cycle progression. While SCF is active throughout the cell cycle, APC gets activated during metaphase to anaphase transition. Cdc20 or Cdh1 binds to APC and...
3.4K
Models of Health Promotion and Illness Prevention II
2.1K
The person's health status fluctuates continually, varying from being in good health to becoming ill and returning to being healthy. To understand the concept of illness prevention, there are two models. First, the health-illness continuum model is a graphic representation of an individual's wellness. It states that a person is considered healthy in the absence of physical disease and the presence of good emotional health.
The agent-host-environment model states that disease results...
The agent-host-environment model states that disease results...
2.1K
Levels of Health Promotion and Illness Prevention
14.5K
Health promotion allows a person to control the determinants of health, resulting in an improved health status. It enhances the quality of life and reduces premature deaths. Health promotion and illness prevention programs help people make beneficial choices to reduce the risk of disease and disabilities. There are three health promotion and illness prevention levels: primary, secondary, and tertiary prevention.
In primary prevention, actions taken before disease onset prevent the disease from...
In primary prevention, actions taken before disease onset prevent the disease from...
14.5K

