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中年のダイエットと後の認知症のリスクとの関連
Tasnime N Akbaraly1,2,3, Archana Singh-Manoux2,4, Aline Dugravot4
1Université Montpellier, Inserm, U1198, Ecole Pratique des Hautes Etudes, Montpellier, France.
JAMA
|March 13, 2019
まとめ
中年の食事の質は,代替健康食指数 (AHEI) を用いて評価され,25年間の追跡期間中に認知症の発症のリスクと有意な関連性は示されなかった. これらの発見は 晩年の認知症の発症の主な要因ではないことを示唆しています
科学分野:
- エピデミオロジー
- 栄養学
- 神経科学
背景:
- 観察研究では,食事と認知の健康との関連が示されていますが,短い追跡期間と不確実な介入試験によって証拠は限られています.
- 認知症の臨床前期が長いため,食事による影響を正確に評価するために長期の研究が必要である.
研究 の 目的:
- 中年の食事の質と 認知症のリスクとの関連を調べる
主な方法:
- 1991年から1993年まで認知症のない8225人の参加者を対象に,集団ベースのコホート研究が行われました.
- 食事の摂取量は,食事の頻度に関するアンケートを使用して,3つの時間点での代替健康的な食事指数 (AHEI) を計算しました.
- 発症した認知症の症例は 電子医療記録によって特定されました
主要な成果:
- 評価期間 (1991年~1993年,1997年~1999年,2002年~2004年) のいずれのAHEIスコアでも,認知症発生率の有意な差異は認められなかった.
- 多変量分析では,AHEIスコアの増加と認知症リスクとの間に有意な関連性はない (調整されたHRは0. 87から0. 97)
- 中年期における食事の質と 長期的な認知症のリスクとの間に統計的に有意な関連性は見つかりませんでした
結論:
- AHEIによって測定された中年の食事の質は,この長期の潜在的なコホートにおける認知症の後のリスクと有意に関連していません.
- 認知症のリスクに影響を与える他の食事パターンや要因を調査するには,さらなる研究が必要かもしれません.
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