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レドックス活性鉄複合体を用いた分子磁気共振画像

Huan Wang1, Veronica Clavijo Jordan1,2, Ian A Ramsay1

  • 1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology , Massachusetts General Hospital/Harvard Medical School , 149 Thirteenth Street , Charlestown , Massachusetts 02129 , United States.

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|March 16, 2019
PubMed
まとめ

Fe-PyC3Aという 新しい鉄基MRIコントラスト剤を 開発しました 生物化学的変化に反応します この薬は,活性酸素種を in vivo で検出することで,炎症の正確なイメージングを可能にします.

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科学分野:

  • 生物化学
  • 医療用イメージング
  • 材料科学

背景:

  • 現在のMRIコントラスト剤は生化学反応が欠けている.
  • 分子イメージングのための標的コントラスト剤の開発は依然として課題です.

研究 の 目的:

  • 生物化学的に反応するMRIコントラスト剤としてFe-PyC3Aという新しいリドックス活性鉄複合体を導入する.
  • 急性炎症の 分子画像の有用性を証明するためです

主な方法:

  • レドックス活性鉄複合体Fe-PyC3Aを合成し,特徴づけました.
  • 磁場強度の範囲 (1.411.7 T) で評価された放緩性変化.
  • 急性炎 (caerulein/LPS) のマウスモデルでの薬剤の効果を評価した.

主要な成果:

  • Fe-PyC3Aは,そのFe3+とFe2+状態の間の磁場独立のリラクシビティの変化の完全な順番を示した.
  • Fe2+- PyC3Aが過酸化水素によって急速に酸化することが観察された.
  • 炎症した臓組織の選択的で強力なコントラスト強化が in vivoで達成されました.
  • 炎症のバイオマーカーであるミエロペロキシダースレベルと強く相関しています

結論:

  • レドックス活性Fe3+/2+複合体は,反応性MRIコントラスト剤を設計するための新しいパラダイムを提供します.
  • Fe- PyC3Aは,リドックス活性によって引き起こされる病理学的変化のインビボMRI画像を可能にします.
  • これは,金属イオンリドックスの最初の in vivo 病理学的イメージングの使用を表しています.