分子正方形と祖母結のステレオ選択合成
David A Leigh1, Lucian Pirvu1, Fredrik Schaufelberger1
1School of Chemistry , University of Manchester , Oxford Road , Manchester M13 9PL , U.K.
Journal of the American Chemical Society
|March 21, 2019
まとめ
研究者達は ステレオセレクティブで 複雑な分子ノードを合成し 祖母と正方形のノードも含む これは,キラルオーバーハンドノートをビルドブロックとして使用して達成され,複雑な分子構造に対する新しいアプローチを示しました.
科学分野:
- 超分子化学
- 有機合成
- ステレオ化学
背景:
- 結び目などの複雑な分子トポロジの合成は化学における重要な課題である.
- チラルのシンソンは,キロンのアプローチに類似した,定義された立体化学を持つ分子を構築するために不可欠です.
研究 の 目的:
- 分子祖母と正方形のノードの ステレオ選択合成を報告する
- ステレオ化学的に定義された"絡み合いのシントン"としてランタニド複合体のオーバーハンドノートを利用する.
主な方法:
- 特殊なハンドルで3回交差するオーバーハンドのノートをエンタグリングシントンとして使用します.
- 銅で触媒化されたアルキネ-アジドサイクル添加 (CuAAC) 反応を用いてシントンを結合する.
- 閉環結節トポロジーを形成するために,閉環結晶メタテシス (RCM) を使用する.
- NMRスペクトロスコーピー,質量スペクトロメトリー,円形二極化による特徴化.
主要な成果:
- 祖母と正方形の分子ノードの両方の ステレオ選択合成が成功しました
- 同じキラリティのシントンと,正方形のキラリティの反対のシントンを組み合わせる.
- トポロジーロック後のランタニドイオンの効率的な除去
結論:
- 開発された戦略は,よりシンプルなキラルビルディングブロックから複雑なノードの構築を可能にします.
- このアプローチは,複雑な分子構造の立体選択合成のための新しい方法を提供します.
- この方法は,超分子化学における絡み合いのシントンの有用性を強調する.
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