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Updated: Jan 27, 2026

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
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BRCA1の募集は,MYCNによる停滞したRNAポリメラーゼの蓄積を制限する

Steffi Herold1, Jacqueline Kalb2, Gabriele Büchel2

  • 1Theodor Boveri Institute, Department of Biochemistry and Molecular Biology, Biocenter, University of Würzburg, Würzburg, Germany. s.herold@uni-wuerzburg.de.

Nature
|March 22, 2019
PubMed
まとめ

神経芽細胞腫におけるMYCNの活性化により,RNAポリメラーゼII (RNAPII) がプロモーターから脱出する. MYCNによるBRCA1徴募は,RNAPIIの停滞を防止し,転写を促進し,腫瘍の生存を助長する.

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