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マイスシロップはマウスの腸内腫瘍の増殖を促す
Marcus D Goncalves1,2, Changyuan Lu3, Jordan Tutnauer1
1Meyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Science (New York, N.Y.)
|March 23, 2019
まとめ
高果糖シロップ (HFCS) の摂取は,マウスの腸内腫瘍のサイズとグレードを著しく増加させた. これは,HFCSがグルコースと併用され,直腸がんの成長を直接促進することを示唆しています.
科学分野:
- 腫瘍学
- 代謝に関する研究
- 胃腸内科
背景:
- 高果糖シロップ (HFCS) の摂取は肥満と結腸直腸がんのリスクの増加と関連しています.
- 腫瘍形成におけるHFCSの直接的な役割は不明である.
- Adenomatous polyposis coli (APC) が変異したマウスは腸内腫瘍に罹患する傾向があります.
研究 の 目的:
- APC変異したマウスの腸内腫瘍の発達に対するHFCSの直接的な効果を調査する.
- HFCSが腫瘍の成長に影響を与える代謝経路を解明する.
主な方法:
- APC変異したマウスにHFCSを毎日投与する.
- 腫瘍のサイズとグレードをモニタリングする.
- フルクトーゼとグルコースの濃度を腸の光と血清で測定する.
- 腫瘍内の糖質の輸送と代謝を分析する
主要な成果:
- HFCSの投与は,腫瘍のサイズとグレードの有意な増加をもたらしました.
- 腫瘍の成長は肥満と代謝症候群とは無関係でした.
- HFCSは腸内と血清の糖分を増加させ,腫瘍は両方を積極的に輸送する.
- 腫瘍内では,フルークトーゼがフルークトーゼ-1-リン酸に変換され,糖分解と脂肪酸合成が活性化されます.
結論:
- フルクトーゼとグルコースの摂取は 適度な量であっても 腸内腫瘍形成を助長する.
- HFCSは腫瘍内の糖質代謝を変化させ,直腸がんの成長を直接促進する可能性があります.
- これらの発見は,HFCSの消費と癌のリスクの増加を結びつける可能性のあるメカニズムを強調しています.
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