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Updated: Jan 27, 2026

In Vivo Modeling of the Morbid Human Genome using Danio rerio
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人口ゲノム学によるヒト疾患の多様性

Ana Prohaska1, Fernando Racimo2, Andrew J Schork3

  • 1Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK; Lundbeck Foundation GeoGenetics Centre, Natural History Museum of Denmark, University of Copenhagen, 1350 Copenhagen, Denmark.

Cell
|March 23, 2019
PubMed
まとめ

人口ゲノミクスは 人口の歴史と局所的な適応が 遺伝疾患の流行にどのように影響しているかを明らかにします これらの進化的要因を理解することは 複雑な病気の遺伝的構造を明らかにする鍵です

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Small population sizes put a species at extreme risk of extinction due to a lack of variation, and a consequent decrease in adaptability. This weakens the chances of survival under pressures such as climate change, competition from other species, or new diseases. Large populations are more likely to survive pressures such as these, as such populations are more likely to harbor individuals that have genetic variants that are adaptive under new stresses. Small populations are much less...
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