胎児の心臓の3次元可視化,運動修正スライス量記録による産前MRIを用いて:前向きな単一センターコホート研究
David F A Lloyd1, Kuberan Pushparajah1, John M Simpson2
1School of Biomedical Engineering & Imaging Sciences, King's College London, King's Health Partners, St Thomas' Hospital, London, UK; Department of Congenital Heart Disease, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Lancet (London, England)
|March 27, 2019
まとめ
この研究では 胎児のMRIと 3Dソフトウェアを組み合わせることで 胎児の血管の高解像度3D画像を 確実に生成することが示されています この高度なイメージングは,標準の2Dエコーカーディオグラフィと比較して,先天性心疾患の診断を改善します.
科学分野:
- 医療用イメージング
- 心血管科学
- 胎児医学
背景:
- 2次元 (2D) 超音波エコーカルディオグラフィーは,先天性心疾患の産前診断の標準です.
- 信頼性の高い二次イメージング,特に3D血管イメージングや低品質の超音波が必要です.
- 胎児のMRIは 胎児の動きに敏感で 3Dイメージングを妨げています
研究 の 目的:
- 産前MRIと 3D画像登録ソフトの組み合わせを調査する
- 胎児の心声検査の補助として,先天性心疾患の診断に有用性を評価する.
主な方法:
- 既知の/疑われる先天性心疾患の胎児の85人がMRI検査を受けた.
- オーダーメイドのオープンソースソフトウェアで 2次元MRIスライスを 超高解像度の3次元ボリュームに再構築しました
- データセットは2D超音波,MRI報告,産後発見と比較した.
主要な成果:
- すべての85例で高解像度の3D胎児胸部データセットが生成されました.
- 3D MRIは,2D MRIと比較して胎児の血管構造の可視化が有意に改善された (97%対53%).
- 観測者は3Dデータをペアリングされた視覚化による症例の90%で高い診断品質と評価した.
結論:
- オープンソースの標準的な胎児MRIは 高解像度3D胎児血管画像を確実に生成します
- 3Dボリュームは2DMRIよりも超音波と優れた可視化/診断品質との良好な一致を示しています.
- 無料で入手できる この方法は安全で強力で 胎児の心血管系を 補完的なイメージングに利用できます
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