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Updated: Aug 16, 2026

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
15:07

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

Published on: December 28, 2015

発現した免疫グロブリン重鎖遺伝子と,Ly 1+ B細胞リンパ腫における生殖系変数遺伝子セグメントの再結合

R Kleinfield, R R Hardy, D Tarlinton

    Nature
    |August 3, 1986
    PubMed
    まとめ

    B細胞の分化には,免疫グロブリン遺伝子の再編成が含まれています. NFS-5リンパ腫における変重 (VH) 遺伝子の間の新しい再結合イベントは,遺伝子配列を置き換えて,埋め込まれたヘプタマー信号を通じて抗体レパートリーを形作る可能性があります.

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