Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Autophagy01:27

Autophagy

5.7K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
5.7K
The Eukaryotic Promoter Region02:40

The Eukaryotic Promoter Region

18.7K
The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences.  The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
18.7K
The Eukaryotic Promoter Region02:40

The Eukaryotic Promoter Region

3.8K
3.8K
Frequency-dependent Selection01:21

Frequency-dependent Selection

23.4K
When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
23.4K
Drug Dependence01:17

Drug Dependence

1.6K
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
1.6K
Anaphase Promoting Complex00:50

Anaphase Promoting Complex

3.3K
The stepwise destruction of specific proteins is necessary for the progression and completion of the cell cycle. Such proteins are ubiquitinated by ubiquitin ligases and then subsequently destroyed by the proteasome. The SCF (Skp1/Cullin/F-box) and the anaphase-promoting complex (APC) are two important ubiquitin ligases involved in cell cycle progression. While SCF is active throughout the cell cycle, APC gets activated during metaphase to anaphase transition. Cdc20 or Cdh1 binds to APC and...
3.3K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Resolving protein condensates and aggregates in vivo by boxcar-enhanced Fluorescence-detected mid-Infrared photothermaL Microscopy (FILM).

Communications chemistry·2026
Same author

FILM: Mapping organellar metabolism by mid-infrared photothermal modulated fluorescence.

ArXiv·2026
Same author

FILM: mapping organellar metabolism by mid-infrared photothermal-modulated fluorescence.

Nature methods·2026
Same author

Fatty acid regulation of feeding in <i>Caenorhabditis</i> elegans reveals the potential ancestral origin of a GLP-1-like multiagonist signaling system.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Form and function of actin impacts actin health and aging.

bioRxiv : the preprint server for biology·2025
Same author

The efficacy of longevity interventions in Caenorhabditis elegans is determined by the early life activity of RNA splicing factors.

PLoS biology·2025
Same journal

A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.

Cell·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
関連記事をすべて見る

関連する実験動画

Updated: Jan 26, 2026

Activating Autophagy by Aerobic Exercise in Mice
08:44

Activating Autophagy by Aerobic Exercise in Mice

Published on: February 3, 2017

12.7K

オートファジー は 長寿 を 促進 し ます か 状況 に かかわる

Marzia Savini1, Meng C Wang2

  • 1Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA; Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.

Cell
|April 6, 2019
PubMed
まとめ
この要約は機械生成です。

オートファギーの誘導とミトコンドリアの透過性は 虫や哺乳類の健康を害し,長寿におけるその役割に挑戦します この研究は,この細胞過程が生物の健康に有害な影響を及ぼすことを明らかにしています.

さらに関連する動画

Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions
12:52

Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions

Published on: September 9, 2014

16.4K
Live Cell Imaging of Early Autophagy Events: Omegasomes and Beyond
09:00

Live Cell Imaging of Early Autophagy Events: Omegasomes and Beyond

Published on: July 27, 2013

19.2K

関連する実験動画

Last Updated: Jan 26, 2026

Activating Autophagy by Aerobic Exercise in Mice
08:44

Activating Autophagy by Aerobic Exercise in Mice

Published on: February 3, 2017

12.7K
Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions
12:52

Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions

Published on: September 9, 2014

16.4K
Live Cell Imaging of Early Autophagy Events: Omegasomes and Beyond
09:00

Live Cell Imaging of Early Autophagy Events: Omegasomes and Beyond

Published on: July 27, 2013

19.2K

科学分野:

  • 細胞生物学
  • 分子生物学
  • 老化に関する研究

背景:

  • オートファギーは細胞リサイクルにおける役割で知られている細胞プロセスで,長寿を促進することがよくあります.
  • オートファギーの正確な影響は,特に他の細胞現象と組み合わせた場合,全体的な生物の健康と寿命には,まだ活発な調査分野です.

研究 の 目的:

  • 結合したオートファギーの誘導とミトコンドリアの透過性の作用を生物の健康に調べる.
  • 長寿に普遍的に役立つという 既成概念に異議を唱えるためです

主な方法:

  • ネマトド Caenorhabditis elegans をモデル生物として利用した.
  • 哺乳類モデルを用いて,観察された効果の保存性を評価する.
  • 誘発されたオートファジーと変異したミトコンドリアの透過性の条件下で,生物の健康と長寿を監視する.

主要な成果:

  • オートファギーの誘導は,ミトコンドリアの透過性の増加に伴い,生物の健康に有害な影響を及ぼします.
  • この否定的な効果はCaenorhabditis elegansと哺乳類のモデルの両方で観察され,保存された生物学的メカニズムを示唆しました.
  • これらの発見は,これらの特定の条件下で長寿を促進するオートファギーの広く受け入れられた有益な役割と矛盾しています.

結論:

  • オートファギーの誘導とミトコンドリアの透過性の増加の組み合わせは健康に有害です.
  • この細胞状態は生物の健康にリスクをもたらし,オートファギーの単純な見方に挑戦します.
  • オートファジー,ミトコンドリア機能,老化との複雑な相互作用を理解するためにさらなる研究が必要である.