Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Catalysis02:50

Catalysis

30.2K
The presence of a catalyst affects the rate of a chemical reaction. A catalyst is a substance that can increase the reaction rate without being consumed during the process. A basic comprehension of a catalysts’ role during chemical reactions can be understood from the concept of reaction mechanisms and energy diagrams.
30.2K
Preparation of Epoxides03:00

Preparation of Epoxides

9.2K
Overview
Epoxides result from alkene oxidation, which can be achieved by a) air, b) peroxy acids, c) hypochlorous acids, and d) halohydrin cyclization.
Epoxidation with Peroxy Acids
Epoxidation of alkenes via oxidation with peroxy acids involves the conversion of a carbon–carbon double bond to an epoxide using the oxidizing agent meta-chloroperoxybenzoic acid, commonly known as MCPBA. Since the O–O bond of peroxy acids is very weak, the addition of electrophilic oxygen of peroxy acids to...
9.2K
Sharpless Epoxidation02:57

Sharpless Epoxidation

5.1K
The conversion of allylic alcohols into epoxides using the chiral catalyst was discovered by K. Barry Sharpless and is known as Sharpless epoxidation. The use of a chiral catalyst enables the formation of one enantiomer of the product in excess. This chiral catalyst is mainly a chiral complex of titanium tetraisopropoxide and tartrate ester (specific stereoisomer). The stereoisomer used in the chiral catalyst dictates the formation of the enantiomer of the product. In other words, the use of...
5.1K
Ligand Binding Sites02:40

Ligand Binding Sites

14.9K
Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
14.9K
Conserved Binding Sites01:49

Conserved Binding Sites

5.1K
Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
5.1K
Structure and Nomenclature of Epoxides02:38

Structure and Nomenclature of Epoxides

7.9K
Cyclic ethers are heterocyclic compounds with an oxygen atom in the ring along with carbon atoms. They are named depending on the number of carbon atoms present in their ring system. Cyclic ethers with a three-membered ring system are called “oxirane”, four-membered ring systems as “oxetane”, five-membered ring systems as “oxolane”, and six-membered ring systems as “oxane”. The cyclic structure of these rings imposes angle strain, and this strain...
7.9K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Current Understandings and Future Opportunities Related to the Structure Direction in Zeolite Synthesis.

ACS applied materials & interfaces·2026
Same author

Effects of Polymer Morphology on Solvent and Catalyst Accessibility during Polyethylene and Polystyrene Autoxidation.

JACS Au·2026
Same author

The ever-evolving active site: transformation of single atoms to extended structures during the Rh-catalyzed reverse water-gas shift reaction.

Faraday discussions·2026
Same author

Coordinatively Unsaturated Aluminum Enables Methanol-Selective CO<sub>2</sub> Hydrogenation With Zeolite-Supported Copper Catalysts.

Angewandte Chemie (International ed. in English)·2026
Same author

Metal hybridization in dilute-alloy catalysts promotes sintering resistance by decreasing surface mobility.

Nature materials·2026
Same author

Probing Terra Incognita of Ni-P Catalysts: <i>Operando</i> Explorations during Hydrogen Evolution Reaction.

Journal of the American Chemical Society·2026

関連する実験動画

Updated: Jan 26, 2026

Forming, Confining, and Observing Microtubule-Based Active Nematics
08:37

Forming, Confining, and Observing Microtubule-Based Active Nematics

Published on: January 13, 2023

3.2K

TiIVの動的再構成と閉じ込め 制御 オレフィンエポキシデーション触媒 二次元ゼオタイプ

Nicolás A Grosso-Giordano1, Adam S Hoffman2, Alexey Boubnov2

  • 1Department of Chemical and Biomolecular Engineering , University of California, Berkeley , Berkeley , California 94720 , United States.

Journal of the American Chemical Society
|April 9, 2019
PubMed
まとめ

シリケートポケット内のチタン触媒部位の閉じ込めは,エントロピックバリアを減らすことによってオレフィンエポキシデーション率を大幅に高めます. ダイナミック・リオーガナイゼーションは 限られた場所の利用に有利で 表面反応制御の新たな手段を 提供します

さらに関連する動画

Creating Two-Dimensional Patterned Substrates for Protein and Cell Confinement
08:36

Creating Two-Dimensional Patterned Substrates for Protein and Cell Confinement

Published on: September 6, 2011

13.1K
Generating Controlled, Dynamic Chemical Landscapes to Study Microbial Behavior
10:07

Generating Controlled, Dynamic Chemical Landscapes to Study Microbial Behavior

Published on: January 31, 2020

6.6K

関連する実験動画

Last Updated: Jan 26, 2026

Forming, Confining, and Observing Microtubule-Based Active Nematics
08:37

Forming, Confining, and Observing Microtubule-Based Active Nematics

Published on: January 13, 2023

3.2K
Creating Two-Dimensional Patterned Substrates for Protein and Cell Confinement
08:36

Creating Two-Dimensional Patterned Substrates for Protein and Cell Confinement

Published on: September 6, 2011

13.1K
Generating Controlled, Dynamic Chemical Landscapes to Study Microbial Behavior
10:07

Generating Controlled, Dynamic Chemical Landscapes to Study Microbial Behavior

Published on: January 31, 2020

6.6K

科学分野:

  • 異質な触媒
  • 表面化学
  • 材料科学

背景:

  • オレフィンエポキシデーションは重要な産業プロセスです.
  • アクティブサイト環境の制御は,触媒性能に影響します.
  • チタンシリケート材料は調整可能な触媒特性を持っています.

研究 の 目的:

  • オレフィンエポキシデーションのための分離されたチタン (IV) 触媒センターに対するダイナミック・コンファインメントの影響を調査する.
  • 活性部位の位置と再編成が触媒活動に与える影響を明らかにする.
  • 浅い表面のポケットの潜在能力を探求する.

主な方法:

  • 制御された封じ込め (非封じ込め対12-MRポケット) のシリケート中心のチタンの合成.
  • ターチルブチル水酸化物を用いたサイクロヘクセンエポキシデーションの運動研究.
  • 電子構造分析のための密度関数理論 (DFT) 計算.
  • 活性化パラメータの熱力学分析 (エンタルピーとエントロピー).

主要な成果:

  • 12MRポケット内の限られたTi (IV) 部位は,限られた部位と比較してエポキシデーションの速度を約5倍に増加させた.
  • ダイナミックな再編は,限られたアクティブサイトを優先的に占有することにつながった.
  • 閉じ込めはエントロピックバリアを減少させ,反応物質の結合と移行状態の形成を容易にした.
  • アクティベーションエンタルピーは一定であり,エントロピーの変化は速度の違いを説明した.

結論:

  • 浅い表面のポケットに部分的に閉じ込められることは,エントロピー効果によって触媒反応性を高めます.
  • ダイナミックな再編成は,活発なサイトを有利な閉じ込められた環境に導く上で重要な役割を果たします.
  • このアプローチは,表面の反応性を制御するための新しい戦略を提示します.