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Updated: Jan 26, 2026

T Cells Capture Bacteria by Transinfection from Dendritic Cells
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保護性抗腫瘍CD4+ T細胞免疫を駆動する2型デンドリティック細胞の解放

Mikhail Binnewies1, Adriana M Mujal1, Joshua L Pollack2

  • 1Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.

Cell
|April 9, 2019
PubMed
まとめ

腫瘍に浸透する骨髄細胞,特に従来型の2型 dendritic細胞 (cDC2) は,抗腫瘍CD4+T細胞の反応を抑制する. 調節性T細胞 (Tregs) の減少はこれを逆転させ,CD4+T細胞の活性を増強し,抗腫瘍保護を改善します.

キーワード:
CD4 ((+) T細胞T細胞のプリミングチェックポイントの封鎖デンドリット細胞免疫療法規制T細胞腫瘍免疫学腫瘍の微小環境

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