化学抵抗を逆転させるための薬剤統合反意味オリゴヌクレオチドから組み立てられた二合一ケモゲン
Quanbing Mou1, Yuan Ma1, Fei Ding1
1School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites , Shanghai Jiao Tong University , 800 Dongchuan Road , Shanghai 200240 , China.
Journal of the American Chemical Society
|April 10, 2019
まとめ
研究者は薬剤耐性がんと闘うために 化学療法と遺伝子治療を組み合わせた 新しい"ケモゲン"投与システムを開発しました このシステムは 抗がん剤をDNAに直接組み込み 治療の効果を高め 薬の感受性を回復します
科学分野:
- バイオメディカルエンジニアリング
- ナノテクノロジー
- ガン 治療
背景:
- 薬剤耐性がんは 臨床的に大きな課題となっています
- 化学療法と遺伝子療法の組み合わせは 抵抗を克服する有望な戦略です
- 既存の薬物投与システムは 化学療法薬と核酸を同時に投与するのに苦労します 異なる性質のためです
研究 の 目的:
- 薬剤耐性がんに対する化学療法と遺伝子治療を統合した新しいナノサイズ薬剤投与システム (DDS) を開発する.
- 抗がん剤をDNAに組み込むことで"ケモゲン"を作り出すこと
- この統合されたDDSの 抗腫瘍効果を証明するために
主な方法:
- ニュクレオシドアナログのフロックスウリジン (F) を反意味DNA配列に組み込み,チミン (T) を置き換えてケモゲンを合成した.
- ケモゲンとポリキャプロラクトンを結合して球状核酸 (SNA) のようなナノ構造を形成した.
- マウスモデルでの細胞侵入,遺伝子ダウンレギュレーション,薬物放出,および in vivo 抗腫瘍有効性を評価した.
主要な成果:
- 化学的DDSは,トランスフェクション剤なしで細胞への急速な侵入を示した.
- 薬剤耐性遺伝子の効率的なダウンレギュレーションが観察されました.
- 持続的な化学療法薬の放出が達成され,皮膚下および正体性肝がんの両方のモデルで著しい腫瘍減少をもたらしました.
結論:
- 薬剤耐性がんの治療に有効な化学療法と遺伝子療法を組み合わせた新薬であるDDSです.
- この統合的アプローチは,異なった治療薬の併用による制限を克服します.
- 化学生成戦略は,がん治療の成果を向上させる大きな可能性を秘めています.
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