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Updated: Jan 26, 2026

Screening for Amyloid Aggregation by Semi-Denaturing Detergent-Agarose Gel Electrophoresis
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Screening for Amyloid Aggregation by Semi-Denaturing Detergent-Agarose Gel Electrophoresis

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アミロイド集積のキラリティ選択化学調節

Nan Gao1, Zhi Du1,2, Yijia Guan1,2

  • 1Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization , Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun , Jilin 130022 , China.

Journal of the American Chemical Society
|April 11, 2019
PubMed
まとめ

チラルポリオキシメタレート誘導体は,β-アミロイドペプチドの結合を効果的に阻害する. フェニララニンで改変されたPOMs,特にd-エナントイオメアは,アルツハイマー病のモデルにおいて重要なエナント選択性と治療的可能性を示しています.

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