食中のオメガ6脂肪酸のバイオマーカーと心血管疾患と死亡率

Matti Marklund^1,2, Jason H Y Wu², Fumiaki Imamura³

¹Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Sweden (M.M., U.R.).

Circulation

|April 12, 2019

まとめ

リノール酸 (LA) とおそらくアラキドン酸 (AA) の高い濃度は,心血管疾患 (CVD) のリスクの低下と関連しています. これらの発見は,CVDの予防におけるLAの保護的役割を支持しています.

科学分野:

栄養学的流行病学
心血管疾患の研究
オメガ6脂肪酸の代謝

背景:

リンオleic酸 (LA) とアラキドン酸 (AA) の総合的な食事推奨と心血管への影響については,議論が続いている.
これらのオメガ6脂肪酸が心血管の健康に果たす正確な役割については不確実性がある.
オメガ6脂肪酸に関する国際的食生活ガイドラインの基礎となる確固たる証拠が必要

研究の目的:

リノール酸 (LA) とアラキドン酸 (AA) と心血管疾患 (CVD) のインビボ濃度の関連性を評価する.
これらの脂肪酸とCVDサブタイプ,冠動脈疾患,不全性脳卒中,心血管死亡率との関係を明らかにする.
オメガ6脂肪酸に関する国際的食事勧告の更新のための証拠を提供すること.

主な方法:

13か国からの30の見通し観察研究の調和した個人レベルの分析.
循環および脂肪組織におけるLAおよびAAバイオマーカーの評価 (総脂肪酸の割合として)
様々なサブグループと遺伝因子の異質性を探求した研究特有の結果のプールメタ分析.

主要な成果:

リノール酸 (LA) の濃度が高いと,全心血管疾患,心血管疾患による死亡率,および不全性脳卒中のリスクが有意に低下した.
アラキドン酸 (AA) レベルは,心血管疾患のリスクの増加と関連していない.
異なる集団のサブグループにおいて,観察された関係において一貫した異質性は認められなかった.

結論:

LAと潜在的にAAのインビボ濃度の上昇は,主要な心血管疾患のリスクの低下と関連しています.
これらの発見は,心臓血管疾患の予防におけるリノール酸の有益な役割を支持しています.
十分なLA摂取が心血管の健康に良い影響を与えるという証拠があります.

キーワード:

アラキドン酸バイオマーカー心血管疾患ダイエット流行病学についてリノール酸主要予防について

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