関連する実験動画

Updated: Jan 26, 2026

Using Sniper-Cas9 to Minimize Off-target Effects of CRISPR-Cas9 Without the Loss of On-target Activity Via Directed Evolution
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Using Sniper-Cas9 to Minimize Off-target Effects of CRISPR-Cas9 Without the Loss of On-target Activity Via Directed Evolution

Published on: February 26, 2019

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CRISPR-Cas9スクリーンを用いたがん治療標的の優先順位付け

Fiona M Behan1,2, Francesco Iorio1,2,3, Gabriele Picco1

  • 1Wellcome Sanger Institute, Cambridge, UK.

Nature
|April 12, 2019
PubMed
まとめ

この研究では,新しい治療標的を特定するために324の癌細胞系におけるCRISPR- Cas9スクリーンを用いた. 重要な発見は,微小衛星の不安定な腫瘍における合成的致死標的としてのワーナー症候群であり,がん薬の開発を進めている.

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