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活性ヒト副甲状腺ホルモン受容体-1の構造と動態

Li-Hua Zhao1, Shanshan Ma1,2, Ieva Sutkeviciute3

  • 1The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Science (New York, N.Y.)
|April 13, 2019
PubMed
まとめ

甲状腺ホルモン受容体-1 (PTH1R) の冷凍-EM構造を決定し,PTHアナログとGタンパク質に結合しました. これは,PTH1Rの活性化がトランスメブランヘリックス6とダイナミックな細胞外ドメインの構成をどのように含むかを明らかにします.

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