ナノスケールメタル・オーガニック・フレームワークは,多種多様な無線強化のためのハイ-Zコンポーネントを階層的に組み合わせる
Journal of the American Chemical Society
|April 19, 2019
まとめ
この研究は,強力な放射増強剤として作用する新しいナノスケール金属有機フレームワーク (nMOF) W18@Hf12-DBB-Irを紹介しています. 98%以上の腫瘍回復率で 優れたがん治療のための反応性酸素種を生成します
科学分野:
- 材料科学
- ナノテクノロジー
- 生物医学工学
背景:
- ナノスケール金属有機フレームワーク (nMOF) は複雑な生物学的機能のための調整可能な多孔性を提供します.
- nMOFに複数の高Z成分を組み込むことは,治療効果を高めることができます.
研究 の 目的:
- 強化された放射性腫瘍学のアプリケーションのための新しいnMOF,W18@Hf12-DBB-Irを合成し,特徴づけること.
- W18@Hf12-DBB-IrによるX線照射による反応性酸素種 (ROS) の相乗生成を調査する.
主な方法:
- Hfベースの金属オクソクラスター,Irベースのリガンド,およびWベースのポリオクソメタレート (POM) をnMOFに階層的に組み込む.
- W18@Hf12-DBB-Irの合成は,Hf12-DBB-IrのフレームワークにW18POMをロードすることによって行われます.
- ROSの生成 (ヒドロキシル基,シングレット酸素,超酸化物) をX線照射で評価する.
主要な成果:
- W18@Hf12-DBB-Irは,ヒドロキシル基,シングレット酸素,および超酸化物生成を著しく強化する.
- nMOFは,ROSによって細胞を殺すというシナジスティック効果を示した.
- 低X線量 (5×1Gy) で>98%の腫瘍回帰を達成した.
結論:
- W18@Hf12-DBB-Irは,がん治療のための有望な多種多様な放射性増強剤です.
- ROSの生成メカニズムは,優れた抗がん効果に寄与する.
- このnMOFは 標的型がん治療戦略における 重要な進歩を象徴しています
関連する概念動画
02:32Bonding in Metals
52.2K
Metallic bonds are formed between two metal atoms. A simplified model to describe metallic bonding has been developed by Paul Drüde called the “Electron Sea Model”.
52.2K
02:37Metallic Solids
20.5K
Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
20.5K
03:06Alkali Metals
24.3K
Group 1 elements are soft and shiny metallic solids. They are malleable, ductile, and good conductors of heat and electricity. The melting points of the alkali metals are unusually low for metals and decrease going down the group, while the density increases going down the group with the exception of potassium (Table 1).
Table 1: Properties of the alkali metals
Table 1: Properties of the alkali metals
24.3K
01:23Components of Stress
512
Stress analysis under multiple loading conditions is intricate, necessitating a comprehensive grasp of normal and shearing stresses. Consider a small cube at point O, subjected to stress on all six faces, visible or not. Normal stress components σx, σy, σz act perpendicularly to the x, y, and z axes. Shearing stress components τxy and τxz are exerted on faces perpendicular to these axes.
Interestingly, the hidden cube faces also experience these stresses, equal and...
Interestingly, the hidden cube faces also experience these stresses, equal and...
512
01:24Components of Language
803
Language, whether spoken, signed, or written, consists of specific components: lexicon and grammar. The lexicon is the vocabulary of a language, comprising its words. Grammar is the set of rules used to convey meaning through the lexicon. For example, English grammar adds “-ed” to most verbs to indicate past tense. Words are formed by combining phonemes, which are the basic sound units of a language. Different languages have different sets of phonemes (e.g., “ah” vs.
803
02:51Metal-Ligand Bonds
24.1K
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
24.1K