関連する実験動画

Updated: Jan 26, 2026

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

14.2K

人間の機能獲得MC4R変種は,シグナルバイアスを示し,肥満から保護します

Luca A Lotta1, Jacek Mokrosiński2, Edson Mendes de Oliveira2

  • 1University of Cambridge MRC Epidemiology Unit, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.

Cell
|April 20, 2019
PubMed
まとめ

メラノコルチン4受容体 (MC4R) 変異は,β-アレスティン信号伝達に影響することで,肥満に影響します. 機能増強型MC4Rは肥満および関連疾患に対する保護を提供しており,治療の可能性を示唆しています.

キーワード:
GPCR についてMC4R についてイギリスのバイオバンク偏ったシグナル遺伝学メラノコルチン肥満β-アレスティン

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