生まれながらの免疫におけるE3リゲーズRIPLETのユビキチン依存および独立の役割

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Updated: Jan 26, 2026

In Vitro Analysis of E3 Ubiquitin Ligase Function
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In Vitro Analysis of E3 Ubiquitin Ligase Function

Published on: May 14, 2021

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Cristhian Cadena1, Sadeem Ahmad2, Audrey Xavier3

  • 1Program in Virology, Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, MA 02115, USA.

Cell
|April 23, 2019
PubMed
まとめ

RIPLETはE3リガゼで,ユビキチン依存的およびユビキチン依存的メカニズムの両方で抗ウイルス免疫を強化します. 共同受容体として作用し,RIG- I受容体のクラスタリングを促進し,ウイルスRNAの長さに基づいて抗ウイルス信号を放大します.

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