Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Cationic Chain-Growth Polymerization: Mechanism00:57

Cationic Chain-Growth Polymerization: Mechanism

The cationic polymerization mechanism consists of three steps: initiation, propagation, and termination. In the initiation step of the polymerization process, the π bond of a monomer gets protonated by the Lewis acid catalyst, which is formed from boron trifluoride and water. The protonation of the π bond generates a carbocation stabilized by the electron‐donating group. In the propagation step, the π bond of the second monomer acts as a nucleophile and attacks the generated carbocation,...
Anionic Chain-Growth Polymerization: Mechanism01:04

Anionic Chain-Growth Polymerization: Mechanism

The mechanism for anionic chain-growth polymerization involves initiation, propagation, and termination steps. In the initiation step, a nucleophilic anion, such as butyl lithium, initiates the polymerization process by attacking the π bond of the vinylic monomer. As a result, a carbanion, stabilized by the electron‐withdrawing group, is generated. The resulting carbanion acts as a Michael donor in the propagation step and attacks the second vinylic monomer, which acts as a Michael acceptor.
Polymers02:34

Polymers

The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...
Polymers02:34

Polymers

The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...
Polymers02:34

Polymers

The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...
Anionic Chain-Growth Polymerization: Overview01:20

Anionic Chain-Growth Polymerization: Overview

The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Facile preparation, structural modulation, and bone-targeting of single-chain polypeptide nanoparticles.

Journal of materials chemistry. B·2026
Same author

Light-programmable, high-drug-loading nanomedicine based on dimeric camptothecin.

Biomaterials science·2026
Same author

Harnessing Self-Assembling Peptides on γδ T Cells to Enhance Anti-Tumor Immunity.

Polymer science & technology (Washington, D.C.)·2026
Same author

Enhanced Renal Accumulation of Polyserine Synthesized from Unprotected Serine <i>N</i>-Carboxyanhydride.

Biomacromolecules·2026
Same author

Mitofusin-Decorated Extracellular Vesicles Enable Targeted Nucleic Acid Delivery to Mitochondria.

Nano letters·2026
Same author

Nanopipette Reference Electrodes with Facile Fabrication and Enhanced Stability.

Analytical chemistry·2026

関連する実験動画

Updated: Jun 15, 2026

Computational Prediction of Amino Acid Preferences of Potentially Multispecific Peptide-Binding Domains Involved in Protein-Protein Interactions
06:50

Computational Prediction of Amino Acid Preferences of Potentially Multispecific Peptide-Binding Domains Involved in Protein-Protein Interactions

Published on: January 26, 2024

"Hinged"ヘリカルポリペプチドにおける近接誘発協同ポリメリゼーション

Chongyi Chen1, Hailin Fu2, Ryan Baumgartner

  • 1Ningbo Key Laboratory of Specialty Polymers, Faculty of Materials Science and Chemical Engineering , Ningbo University , Ningbo 315211 , China.

Journal of the American Chemical Society
|April 25, 2019
PubMed
まとめ

研究者は,N-カルボキシアンヒドリド (NCAs) とダイアミンイニシアターを使用して,急速なポリペプチド合成方法を開発した. この協同的ポリメリゼーションプロセスは,ヒンジ付きの螺旋構造によって可能になり,鎖の成長を大幅に加速します.

さらに関連する動画

Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles (PPAs) and Related Biomaterials
08:55

Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles (PPAs) and Related Biomaterials

Published on: June 25, 2018

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
09:22

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives

Published on: February 7, 2017

関連する実験動画

Last Updated: Jun 15, 2026

Computational Prediction of Amino Acid Preferences of Potentially Multispecific Peptide-Binding Domains Involved in Protein-Protein Interactions
06:50

Computational Prediction of Amino Acid Preferences of Potentially Multispecific Peptide-Binding Domains Involved in Protein-Protein Interactions

Published on: January 26, 2024

Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles (PPAs) and Related Biomaterials
08:55

Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles (PPAs) and Related Biomaterials

Published on: June 25, 2018

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
09:22

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives

Published on: February 7, 2017

科学分野:

  • ポリマー化学
  • バイオミメティック素材
  • 合成生物学

背景:

  • 生物学的なシステムは プロセス規制のために 協力的な相互作用を効果的に利用する.
  • ポリペプチド合成は,バイオ材料と治療薬を含む様々な用途に不可欠です.
  • 高度なポリマーアーキテクチャの設計には,ポリメリゼーション運動を制御することが重要です.

研究 の 目的:

  • N-カルボシアンヒドリド (NCAs) の新しい,自動加速された協同ポリメリゼーションを報告する.
  • ポリペプチド合成のイニシアターとして単純な線形アリファティックダイアミンの使用を調査する.
  • 螺旋構造によって誘発される協同ポリメリゼーションのメカニズムを解明する.

主な方法:

  • ポリメリゼーションのためのモノマーとして利用されたN-カルボシアン水素 (NCAs).
  • 線形アリファティックダイアミン (例えば1,6-ダイアミノヘキサン) をポリメリゼーションイニシアターとして使用しています.
  • "ヒングド"ポリペプチドの形成に焦点を当てて,ダイアミンによるポリメリゼーションの運動学とメカニズムを分析した.

主要な成果:

  • 協同ポリメリゼーションによって高速で自動加速したポリペプチド合成を達成した.
  • ダイアミンのイニシアチブは,ヘッド・トゥ・ヘッドで接続された螺旋鎖を持つ"ヒングド"ポリペプチドにつながることを実証した.
  • モノアミンの開始と比較して,ヒンジ付きの螺旋構造のマクロディポールの間の協力的相互作用に起因する,劇的なポリメリゼーション率 (600倍以上) が観察されました.

結論:

  • この研究は,協同ポリメリゼーションを用いた効率的なポリペプチド合成のための新しい方法を示しています.
  • ダイアミン誘導で形成された"ハングド"ポリペプチドは,強化されたポリメリゼーション運動を示します.
  • 単一の螺旋構造は,合成化学における協力性を可能にするために効果的なモチーフとして機能し,先進的な材料設計の経路を提供します.