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Updated: Jan 25, 2026

Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
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化学選択ヒスティジンの生物結合のためのバイオインスピレーションのチオホスフォロジクロリデート反応剤

Shang Jia1, Dan He1, Christopher J Chang1,2,3

  • 1Department of Chemistry , University of California , Berkeley , California 94720 , United States.

Journal of the American Chemical Society
|April 25, 2019
PubMed
まとめ

研究者らは,タンパク質のヒスティジン残基を修正する新しい方法を開発し,標的型機能化を可能にしました. このヒスティジンの改変戦略は,特定の荷重分子を結合することによって,細胞へのタンパク質の供給を強化します.

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