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人間のMT1メラトニン受容体におけるリガンド認識の構造的基礎

Benjamin Stauch1,2, Linda C Johansson1,2, John D McCorvy3,4

  • 1Bridge Institute,USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA.

Nature
|April 26, 2019
PubMed
まとめ

メラトニン受容体1 (MT1) が不眠症薬やアゴニストに結合する構造を決定しました これらの発見は,独特のリガンドエントリーメカニズムとアロマティック相互作用を明らかにし,日中リズム障害に対する将来の薬剤設計を支援しています.

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