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Updated: Jan 18, 2026

Using En Face Immunofluorescence Staining to Observe Vascular Endothelial Cells Directly
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SR-B1はDOCK4経由で内皮細胞のLDLトランサイトスを駆動し,動脈硬化を促進する

Linzhang Huang1, Ken L Chambliss1, Xiaofei Gao2,3,4,5

  • 1Center for Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Nature
|April 26, 2019
PubMed
まとめ

内皮細胞のスキャベンジャー受容体SR-B1は,LDLコレステロールを動脈壁に積極的に輸送し,動脈硬化を促進します. この発見は,LDLの被動的な侵入に異議を唱え,心臓血管疾患の新たな治療目標を示唆しています.

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