関連する実験動画

Updated: Jan 25, 2026

Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE
12:43

Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE

Published on: July 29, 2014

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循環型RNAの構造と分解は,先天性免疫におけるPKR活性化を調節する

Chu-Xiao Liu1, Xiang Li1, Fang Nan2

  • 1State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.

Cell
|April 30, 2019
PubMed
まとめ

循環型RNA (circRNAs) は,先天的な免疫酵素PKRを阻害する安定した分子である. 早期の免疫反応には 降解が不可欠で 減少はSLEのような 自己免疫疾患と関連しています

キーワード:
PKR についてRNase L について自己免疫疾患circRNAの分解circRNA構造サークルRNAs円形のRNA二重鎖RNA生まれつきの免疫反応全身性赤血性狼

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